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1996-03-09
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Document 0324
DOCN M9650324
TI Autopsy-proven causes of death in HIV-infected patients treated for
tuberculosis in Abidjan, Cote d'Ivoire.
DT 9605
AU Greenberg AE; Lucas S; Tossou O; Coulibaly IM; Coulibaly D; Kassim S;
Ackah A; De Cock KM; Projet RETRO-CI, Abidjan, Cote d'Ivoire.
SO AIDS. 1995 Nov;9(11):1251-4. Unique Identifier : AIDSLINE MED/96126179
AB OBJECTIVE: To determine autopsy-proven causes of death in HIV-infected
patients treated for tuberculosis in Abidjan, Cote d'Ivoire. METHODS: A
computerized listing of 9523 patients diagnosed with tuberculosis and
tested for HIV infection at Abidjan's two large tuberculosis treatment
centers from July 1989 to December 1991 was matched against a listing of
496 patients who were autopsied in Abidjan's largest public hospital in
1991-1992. RESULTS: Fifteen matching patients were identified including
11 adults with smear-positive pulmonary tuberculosis, three adults with
extrapulmonary tuberculosis, and one child with smear-negative pulmonary
tuberculosis. The autopsy-proven causes of death among the adults were
tuberculosis (n = 4), bacterial infections (n = 3), cerebral
toxoplasmosis (n = 2), pulmonary nocardiosis (n = 2), Pneumocystis
carinii pneumonia (n = 1), atypical mycobacteriosis (n = 1), and wasting
syndrome (n = 1). Tuberculosis was the primary cause of death in two of
five smear-positive patients who had not completed therapy, in none of
the six patients with smear-positive disease who had completed therapy,
and in two of the three patients with extrapulmonary tuberculosis.
CONCLUSIONS: Chemoprophylaxis with trimethoprim-sulfamethoxazole
(TMP-SMX) might have provided benefit to eight (57%) of the 14 adults in
this series who died either of bacterial infections, toxoplasmosis,
nocardiosis, or pneumocystosis. Prospective studies are required to
elucidate further the causes of increased mortality, and to evaluate the
benefits of TMP-SMX prophylaxis in HIV-infected African patients with
tuberculosis.
DE Adult Autopsy Cause of Death Child, Preschool Cote d'Ivoire Female
Human HIV Infections/*COMPLICATIONS/MORTALITY Male Middle Age
Tuberculosis/ETIOLOGY/MORTALITY/*PATHOLOGY Tuberculosis,
Pulmonary/ETIOLOGY/MORTALITY/*PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).